Investigating the interaction between dengue virus and the immune system
Latest Publication
Our newest work using transcriptomics to investigate the immune profiles of macrophages infected with DENV via ADE
Publications
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Proceedings of the second annual dengue endgame summit: A call to action
Hardy CSC, Bahr LE, Rothman AL, Anderson KB, Barba-Spaeth G, Weiskopf D, Ooi E, Marques ETA, Bonsignori M, Barrett ADT, Kirkpatrick BD, Castanha PMS, Hamins-Puertolas M, Christofferson RC, Dimopoulos G, Oliveira F, Chiang LW, Ko AI, Gunale B, Kulkarni P, Perkins TA, Dorgatti I, Stewart T, Shaw J, Johansson MA, Thomas ST, Waickman AT.
PLoS Negl Trop Dis.
2025 Apr 28;19(4):e0013028
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Conventional and antibody-enhanced DENV infection of human macrophages induces differential immunotranscriptomic profiles
Hardy CSC, Wegman AD, Waldran MJ, Chan GC, Waickman AT.
J Virol.
2025 Mar 18;99(3)
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Development and optimization of an mRNA-vectored single-chain IgA1 isotype monoclonal antibody with potential to treat or prevent dengue virus infection
Thanh N, Gebo C, Lu J, Popoola DO, Thomas SJ, Li Y, Waickman AT.
Antiviral Res.
2025 Feb:234:106078
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B cell receptor dependent enhancement of dengue virus infection
Gebo C, Hardy CSC, McElvany BD, Graham NR, Lu JQ, Moradpour S, Currier JR, Friberg H, Gromowski GD, Thomas SJ, Chan GC, Diehl SA, Waickman AT.
PLoS Pathog.
2024 Oct 31;20(10)
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Efficacy and immunogenicity following dengue virus-1 human challenge after a tetravalent prime-boost dengue vaccine regimen: an open-label, phase 1 trial
Lyke KE, Chua JV, Koren M, Friberg H, Gromowski GD, Rapaka RR, Waickman AT, Joshi S, Strauss K, McCracken MK, Gutierrez-Barbosa H, Shrestha B, Culbertson C, Bernal P, De La Barrera RA, Currier JR, Jarman RG, Edelman R.
Lancet Infect Dis.
2024 Aug;24(8)
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Dengue Virus Structural Proteins Are Expressed on the Surface of DENV-Infected Cells and Are a Target for Antibody-Dependent Cellular Phagocytosis
Waldran MJ, Kurtz EA, Gebo CJ, Rooney TJ, Middleton FA, Roy NH, Currier JR, Waickman AT.
Open Forum Infect Dis.
2024 Dec 11;12(1)
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Soluble NS1 Antagonizes IgG- and IgA- Mediated Monocytic Phagocytosis of DENV Infected Cells
Waldran MJ, Wegman AD, Bahr LE, Roy NH, Currier JR, Waickman AT.
J Infect Dis.
2023 Jun 28;228(1):70-79.
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Proceedings of the dengue endgame summit: Imagining a world with dengue control
Wegman AD, Kalimuddin S, Marques ETA, Adams LE, Rothman AL, Gromowski GD, Wang TT, Weiskopf D, Hibberd ML, Perkins TA, Christofferson RC, Gunale B, Kulkarni PS, Rosas A, Macareo L, Yacoub S, Ooi E,Paz-Bailey G, Thomas SJ, Waickman AT.
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Evolution of inflammation and immunity in a dengue virus 1 human infection model
Waickman AT, Lu JQ, Fang H, Waldran MJ, Gebo C, Ware L, Van Wesenbeeck L, Verpoorten N, Lenz O, Tambuyzer L, Herrera-Taracena G, Van Loock M, Endy TP, Thomas SJ.
Sci Transl Med.
2022 Oct 26;14(668)
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DENV-specific IgA contributes protective and non-pathologic function during antibody-dependent enhancement of DENV infection
Wegman AD, Waldran MJ, Bahr LE, Lu JQ, Baxter KE, Thomas SJ, Waickman AT.
PLoS Pathog.
2023 Aug 28;19(8):e1011616.
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Inflammation, immunity, and antigen persistence in post-acute sequelae of SARS-CoV-2 infection.
Newell KL, Waickman AT.
Current Opinion in Immunology
2022 May 24;77:102228.
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mRNA-1273 vaccination protects against SARS-CoV-2-elicited lung inflammation in nonhuman primates.
Waickman AT, Victor K, Newell K, Li T, Friberg H, Foulds KE, Roederer M, Bolton DL, Currier JR, Seder R.
JCI Insight.
2022 Jul 8;7(13):e160039
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Systemic Cancer Therapy Does Not Significantly Impact Early Vaccine-Elicited SARS-CoV-2 Immunity in Patients with Solid Tumors
Waickman AT, Lu J, Chase C, Fang H, McDowell E, Bingham E, Bogart J, Graziano S, Thomas SJ, Gentile T.
Vaccines (Basel).
2022 May 9;10(5):738.
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Simultaneous analysis of antigen-specific B and T cells after SARS-CoV-2 infection and vaccination.
Newell KL, Waldran MJ, Thomas SJ, Endy TP, Waickman AT.
Cytometry A. 2022 Jun;101(6):474-482
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Interleukin-2-inducible T-cell kinase (Itk) signaling regulates potent noncanonical regulatory T cells.
Mammadli M, Harris R, Suo L, May A, Gentile T, Waickman AT, Bah A, August A, Nurmemmedov E, Karimi M.
Clin Transl Med. 2021 Dec;11(12):e625
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Monomeric IgA Antagonizes IgG-Mediated Enhancement of DENV Infection.
Wegman AD, Fang H, Rothman AL, Thomas SJ, Endy TP, McCracken MK, Currier JR, Friberg H, Gromowski GD, Waickman AT.
Frontiers in Immunology
2021 Nov 24;12:777672
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Stochastic Model of the Adaptive Immune Response Predicts Disease Severity and Captures Enhanced Cross-Reactivity in Natural Dengue Infections.
Nguyen HD, Chaudhury S, Waickman AT, Friberg H, Currier JR, Wallqvist A.
Frontiers in Immunology
2021 Aug 17;12:696755
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Human Wnt/β-Catenin Regulates Alloimmune Signaling during Allogeneic Transplantation
Mammadli M, Harris R, Mahmudlu S, Verma A, May A, Dhawan R, Waickman AT, Sen JM, August A, Karimi M.
Cancers (Basel).
2021 Jul 28;13(15):3798
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Identification and successful management of near-lethal ventricular tachycardia in 2q24 deletion-associated developmental and epileptic encephalopathy.
Toth J, Waickman A, Jost J, Seltzer L, Vinocur JM, Auerbach DS.
Seizure.
2021 Oct;91:146-149.
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Persistent COVID-19 Symptoms Minimally Impact the Development of SARS-CoV-2-Specific T Cell Immunity.
Fang H, Wegman AD, Ripich K, Friberg H, Currier JR, Thomas SJ, Endy TP, Waickman AT
Viruses.
2021 May 15;13(5):916
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Enhanced dengue vaccine virus replication and neutralizing antibody responses in immune primed rhesus macaques.
McCracken MK, Kuklis CH, Kannadka CB, Barvir DA, Sanborn MA, Waickman AT, Siegfried HC, Victor KA, Hatch KL, De La Barrera R, Walls SD, Rutvisuttinunt W, Currier JR, Friberg H, Jarman RG, Gromowski GD.
NPJ Vaccines.
2021 May 21;6(1):77
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Targeting SLP76:ITK interaction separates GVHD from GVL in allo-HSCT.
Mammadli M, Huang W, Harris R, Xiong H, Weeks S, May A, Gentile T, Henty-Ridilla J, Waickman AT, August A, Bah A, Karimi M.
iScience.
2021 Mar 11;24(4):102286
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Temporally integrated single cell RNA sequencing analysis of PBMC from experimental and natural primary human DENV-1 infections.
Waickman AT, Friberg H, Gromowski GD, Rutvisuttinunt W, Li T, Siegfried H, Victor K, McCracken MK, Fernandez S, Srikiatkhachorn A, Ellison D, Jarman RG, Thomas SJ, Rothman AL, Endy T, Currier JR.
PLoS Pathogens
2021 Jan 29;17(1):e1009240